About the Network

The Cholestatic Liver Disease Consortium (CLiC) is a collaborative team of doctors, nurses, research coordinators, and patient support organizations throughout the US and UK, working together to improve the lives of children and families dealing with rare Cholestatic Liver Diseases. The goal of the CLiC team is to investigate five genetic causes of intrahepatic cholestasis and to train the next generation of clinical researchers. These five diseases are:

  • Alpha-1-antitrypsin (a-1AT) deficiency
  • Alagille syndrome (AGS)
  • Progressive familial intrahepatic cholestasis (PFIC)
  • Bile acid synthesis and metabolism defects
  • Mitochondrial hepatopathies

The purpose of this consortium is to provide a way for patients to join with doctors and researchers by participating in research studies. The greater the collaboration between doctors and patients and their families, the more we can learn about cholestatic liver diseases. This important first step is necessary if we are to find new and better treatments. CLiC can help you:

  • Obtain helpful information about these diseases
  • Stay up to date with new developments
  • Become aware of clinical research and clinical trial opportunities
  • Connect with patient support groups

The centers that make up CLiC are:

Clinical Centers:

Baltimore, Maryland
Johns Hopkins School of Medicine
Kathleen Schwarz MD, Principal Investigator

Chicago, Illinois
Children's Memorial Hospital
Peter Whitington MD, Principal Investigator

Cincinnati, Ohio
Children's Hospital Medical Center
James Heubi MD, Principal Investigator

Denver, Colorado
The Children's Hospital
Ronald Sokol MD, Principal Investigator

Houston, Texas
Texas Children's Hospital
Saul J. Karpen MD, PhD, Principal Investigator

Indianapolis, Indiana
Riley Hospital for Children
Jean Molleston MD, Principal Investigator

Los Angeles, California
Children's Hospital of Los Angeles
Kasper Wang MD, Principal Investigator

New York, New York
Mount Sinai Medical Center
Frederick Suchy MD, Principal Investigator

Philadelphia, Pennsylvania
Children's Hospital of Philadelphia
David Piccoli MD, Principal Investigator

Pittsburgh, Pennsylvania
Children's Hospital of Pittsburgh
Benjamin Shneider MD, Principal Investigator

San Francisco, California
University of California, San Francisco
Philip Rosenthal MD, Principal Investigator

Seattle, Washington
Seattle Children's Hospital
Karen Murray MD, Principal Investigator

St. Louis, Missouri
St. Louis University School of Medicine
Jeff Teckman MD, Principal Investigator

Toronto, Ontario, Canada
The Hospital for Sick Children
Vicky Ng MD, Principal Investigator

Washington University School of Medicine
Yumi Padron-Turmelle MD, FRACP, FRCP, Principal Investigator



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Comments/Requests to:borc-admin@umich.edu Last build:   03/14/2014 11:52:29